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On the other hand, there is extensive evidence that people who eat more vegetables and fruits-foods that are rich sources of antioxidants-have lower risks of chronic diseases. In general, except for age-related macular degeneration, there is currently no evidence that antioxidant supplements have a positive impact on these diseases. Each of the many antioxidants found in the body has different properties. In addition, different types of antioxidants may not be interchangeable. Large amounts of antioxidants may interfere with important functions in the cell, including its defense mechanisms and normal signaling. These small molecules are the focus of this fact sheet.Īs research has progressed, it has become evident that antioxidants-especially in larger-than-usual amounts-may not always be beneficial.

Phytochemicals that act as antioxidants may also play a role in helping regulate oxidative stress pathways. Research has shown that antioxidant enzymes are the most important components of this defense system. Our bodies have preventive and repair mechanisms that regulate oxidative stress pathways.

Overproduction of these substances can lead to a condition called “oxidative stress,” which may damage cells and contribute to chronic diseases such as heart disease and cancer.

During their normal activities, our bodies’ cells produce highly reactive substances that contain oxygen.

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